Melanoma Clinical Trials
A Phase 1b/3 study of Talimogene Laherparepvec in combination with pembrolizumab (MK-3475) for treatment of Stage IIIB to IVM1c Melanoma that cannot be surgically removed (20110265 MASTERKEY-265).
- Patients with BRAF wild-type mutations may have had chemotherapy, immunotherapy, or targeted therapy in an adjuvant setting (additional treatment to primary treatment) for cancer that cannot be surgically removed.
- Patients may have received the following treatment ONLY in the adjuvant setting: anti-CD137, ipilimumab or other CTLA-4 inhibitor, talimogene laherparepvec, tumor vaccine, or any other oncolytic viruses or drugs specifically targeting T-cell co-stimulation or checkpoint pathways.
- Patients treated with BRAF inhibitors with, or without a MEK inhibitor as their only prior systemic treatment are eligible for this study.
- Patients may not have received treatment with pembrolizumab, or any other inhibitor of PD-1, PD-L1, and PD-L2.
A Phase 1b/3, Multicenter, Trial of Talimogene Laherparepvec in Combination With Pembrolizumab (MK-3475) for Treatment of Unresectable Stage IIIB to IVM1c Melanoma (MASTERKEY-265).
MASTERKEY‐265 is a phase 1b/3 clinical trial that will evaluate the safety and efficacy of the investigational combination of these two different immunotherapies (talimogene laherparepvec and pembrolizumab) in patients with advanced melanoma. Advanced melanoma has usually spread to other parts of the skin, regional or distant lymph nodes, lungs, or liver. In addition, the advanced disease cannot be cured with surgery alone.
MAVIS: A Multi-center, Double-blind, Placebo-controlled, Adaptive Phase 3 Trial of POL-103A Polyvalent Melanoma Vaccine in Post-resection Melanoma Patient with a High Risk of Recurrence
The purpose of this study is to determine how safe and how well POL-103A works in preventing the relapse of melanoma in patients who have previously undergone resection surgery.
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